effects of variations of flow and heart rate on intra-aneurysmal hemodynamics in a ruptured internal carotid artery aneurysm during exercise

conclusion results reinforced the pivotal role of vascular geometry, with respect to hemodynamics, together with the importance of performing patient-specific cfd analyses, through which the effect of different blood flow conditions on the aneurysm hemodynamics could be evaluated. objectives this study aimed to investigate the effects of variations in heart rate and internal carotid artery (ica) flow rate on intra-aneurysmal hemodynamics, in an ica aneurysm, by using computational fluid dynamics. patients and methods computed tomography angiography (cta) was performed in a 55 years old female case, with a saccular ica aneurysm, to create a patient-specific geometrical anatomic model of the aneurysm. the intra-aneurysmal hemodynamic environments for three states with different flow and heart rates were analyzed using patient-specific image-based cfd modeling. results results showed significant changes for the three simulated states. for a proportion of the states examined, results were counterintuitive. systolic and time-averaged wall shear stress and pressure on the aneurysm wall showed a proportional evolution with the mainstream flow rate. background hemodynamics is thought to play an important role in the mechanisms responsible for initiation, growth, and rupture of intracranial aneurysms. computational fluid dynamic (cfd) analysis is used to assess intra-aneurysmal hemodynamics.